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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '187f3ccd38361681cc39b7c180374556e328010dacf37d5802e450ad70c133c1' 
  AND token = '4Vxk2BdOC02aAIvdHJcbBHsTMxDM/NFaOC4IzmRN/tc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}