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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '28b911e40c6b2a0e9b5af31a30689ef270ee90d60fed0410cdd3d037f8ec94c6' 
  AND token = 'UMkD6E0fUUEBxU/Fb1y691bYjTxaPh5t8xUHPRfP5NE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}