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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21f5b1d928d311a56f0b1b38062a49f105c1794b3bb21ede8cf115c36734e7ac' 
  AND token = 'z3y2LXlJ+00otQfTbdNMVy/oCgCPB4J6SMD7tE9wLkE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}