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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f96ee4fb75288339ec5f9a65a5ebed4e74b98ab7ac507025c24e882808fa2180' 
  AND token = 'uDxSRGZUdO+xHpGIz5HPVVebwsWzSdEnX9a24dZyS88=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}