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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3219a0c1a4a5a9378bf00466b20f989c3ca4f15727473bcec81c5ef7e2f78ff8' 
  AND token = '+CRkbWGV4SN8Z/0WOuyh/u45K7Gi/4sdq/hisbLe8Wo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}