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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45bd45fef03488294c399446f04fdbb3c266ca8266fa7137d88817f32c9bd787' 
  AND token = 'h827HiaD7QK5V+Sr0NZ/FEcp489hT9A2u9f3e7YzUJo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}