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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '878a4e5f3d7baba7619370c4f22cf22a3b88f6fd5cd5fc80f4cdc8edf80038e6' 
  AND token = '0bLqUMt3BQZVVpzKcVYZa0JPbc6VJUlgNNH2qcFkxb4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}