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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '10541c55cf6b90d923fa39edd22fc61170cee64e250d22a0cc159568b4e69356' 
  AND token = 'u4xSkV2wQuemL5lXs1cKAFSOrfXmHjzYWWKfkE8S4IY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}