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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b783817ea62a242d923c9a2f97e925779e3bd79d1dd277960d59402647e0bc5f' 
  AND token = '+EsaadaKsICeA0kHTDHTMl4UOYNpvAhdNhJgXxFRJm0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}