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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1a906f7c538f101fbd6947bb610861e90e416dc150f681f73a10f0644c46f91f' 
  AND token = 'l1637mBGiiz8N4Yo/DAdRzGjmWPtBzG5zcrhOny9b10=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}