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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '44ecf04cc4d1b934c3e00830e934635be0b85e4714287c78358c95c379049ba4' 
  AND token = 'ZtamlMLFuRVUr0Q23UU0QUxA7FosscN2vEzbqxg6OUc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}