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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3c5e80e5c07b8cb3e4fedd1da131b14943f49b46291f5ea3b37301597aa07a1e' 
  AND token = 'P5wyl+j9UHrdUDcOv+5GAA9lyyDx3rK2yFtG1Jow5Ic=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}