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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7c2203e0b44d38478cd03dfc2a28fdfde215bc221ccffdad1b9884e580d7f221' 
  AND token = 'S+y4VvKdxZttqzZ/hOoBuRMicqPaLqAUlC+NkFXph/Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}