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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c8ea52142ddf18c67e51155141212c15cf7376e48e720444e0b507424dfbcd58' 
  AND token = 'IiU3vILrN2ehjwNYMKFtQXyirVnJpTkJsCU7PgZyB6U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}