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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5e216772aea51b9e5fc424446c2ca784b05eb30e3783492ed54f1a0e0ea686eb' 
  AND token = 'UgcSExibLj7Xznz7+fqy9rlZXYr6vDYVEZIWOR4kRss=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}