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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2d4c0860b37f2183fa44f80645d370daf43f24c6e1c9fb7e97eb7991d1022326' 
  AND token = 'YVUWEvtSThvtr5IV+EvbuLluUZvxW5QdlhP38lDOplo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}