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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21573828262a21453666d8e5183b32148a5808aa7d7b962b29c26a65da0138e7' 
  AND token = 'Lc3VUsxRb+nthhBofh4V7S7Y6KEXkS0b5U0U/uTNwPE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}