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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5e9f5e3b9cfb272490716fbb9d18d262662d1141a2705575043d1f7921a796a2' 
  AND token = 'HLxNmh6GP5h2HXneHrfMDPwSW/+0VB5Q6Kuy+Nldv9E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}