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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21d61ce503332d417165c24fa7c9f7bd0ae0c5b998a2717b5933c7d1e7db91cc' 
  AND token = 'x9VUswrnqCfAEnxFR2/9Fpe9zsdITT+WZ49jim6pu9E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}