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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ce453aeb5c92f23518755b7967dfd20b24627092b1f6ab0610bd68b85210c288' 
  AND token = '/KIz3Lsfx5sweGRw+Tk95mPerWa3hnYxkkbTBsoruJQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}