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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8bb879881f1be8c1fc1e055f716ef2087a167058432565795ea3b645c0355001' 
  AND token = 'MedFtMqlLZBC46hoSiOeoFfR4GWaxGzj7/PW4Ize2Z4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}