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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45ee0c3762d0c243bdbd23fcbe5720be565fea6521c0d8f424dc4e78eeb6f19c' 
  AND token = 'qQELp/VAKaZCi3MSdNdCqbaHxrX7v06knM2nAmT51vU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}