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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b553f72b3509f37dbf863d21ab01f50df9c6bf338913e1a3b801ff61801dd317' 
  AND token = 'bc5DDUHralE6OTaopuFnQGW5xgnLPD1MVh8LLuP1iZ8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}