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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3340baa2df3883de33674be0b327a023aecc3f1d7924c27fb00b71f1a6838742' 
  AND token = 'ldOfBO1IwXtPSXmqpQWsrcSQLeNXNvmWGV+eIs3wCEQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}