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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '721d25746e6ffd8359d1d9c32761616f1a053c34483912085ee37a7e1e925532' 
  AND token = '76WBZywD9V3Ptnsa+BwYPlxRehUhyawoQFbo4e7bM+E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}