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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '66074e0d101165dde828bdff774f3987305a8203297f7bfecb1080e1e1988680' 
  AND token = 'ROmADVYoQm7el7Vvy/tIjHKWZFm19hkt+gAycCVmrWY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}