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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '129f9f59fbf15e06a01ffc3bd83b57a2193e25dff3625c1080726db9c3e01386' 
  AND token = 'OnQq5cPVlGyNh9ioZc3G0AHcMzrd8ZkrvAzRKhi2CKU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}