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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5200d22c7d2cdef53456cab4f414951516361e6e2ccf94f3eebb69aa6d82040e' 
  AND token = 'vj1Jl5yf1iECaGLHKDyh3RjrgKXoB0u55O2jXAzDN6Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}