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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '220c40a4854a8e2a5a11c80c2873882c6bec21e6f5b6ab7846bbbd0a648f6ac2' 
  AND token = 'DXwMOcI8tdUwWrrPF+vcCjh7hBP4b5Fr1XviWVTJZj8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}