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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3a2b43b2f6a2b0cc1630678f3c432c3e659875381498b9dce8b1f5f38de82208' 
  AND token = 'oI4IOb3AZZVwh8yddJqGAsM2nPekWoQ6HQb+rG46xJ0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}