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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '621d4032ec64c6f6c4acc1543bb073d33ab614c0561dc7f1c6128bfd49d9126a' 
  AND token = 'wVA1SCYP0rRc7wLZhH7Ko+Qx1L627CtVoVN7aDZyv8g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}