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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e8f12f6c9ce65a4f51541d0cef71844c06ced40aceb1956282d7dd92a2e2c134' 
  AND token = 'c1ONR1beUhVo+jv2qLl78r6zL8DnyHHTAW/FCzYzLbs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}