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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1e81646ea8223aebbfd36dc89140b2dc53a271fc647cb9be1b0243ad06e45922' 
  AND token = 'UXCpP5p3RarA3wWEo2c68gSeraV6HjKnct7Y0Qn46aE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}