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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42c3dac2074bd495904c04f2fe49dcde56c01974fa0f3ed4be06da82e429aa57' 
  AND token = '/hQ2hCgxL/y6exd+V0Kro8NJ7RrX8iP2m8EpzoWJeJc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}