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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '33e42d299cacf25574f8672750e253549c2af32bf7bfc6fd1cef05cf8f6ca9bd' 
  AND token = 'RF7dw687AbgRn8ZxCmMNsBT3hasZ+qa6hI7z+DCW+AY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}