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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fe01340e80f1d0b1d54e75b3a4821cb0885bac760e4b3f681b035b928a161fb6' 
  AND token = 'gUO4b2lHyEEffRqkR0CwnV3hk2EIIGoHHN+8qzaWCgY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}