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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '250ce87be807c8c88481b26e4ba8e0630285eb05de1f77c7865d3fb23648cdc4' 
  AND token = 'UEj7YVb0H8RdE9sGMMC+6TSKIh/w0ZrdW93k3STAQas=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}