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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5853b1aba7ffb77db33746e17746804b7e3f0815934f2eb5f2bfc4a5c3e16a04' 
  AND token = '2ACon2ovwsmsD3TXKsPbPx8nTHPvBz0oQGIS3O0Yzqc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}