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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '144bc0b00c726a596f5d020ec09d9bd2047c678b811d91dc9340e12a75bc7df9' 
  AND token = '52EbIKqe8SDH2+E/VjUWsNDfAW5ZZmvDvhL7HXM54iA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}