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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '67edf0747451d310c90a80c4f1b60d7d787bf3997fdf71268fc1d826990f0d5f' 
  AND token = 'eOttlFOiiUwOrN4tEynckEa3gn6u6d3XXFrbtDRcpDA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}