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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b6478e3253621f08d668ac9aeb290245f0a514e676427abb16534c690cd5f1ea' 
  AND token = 'XkTDPz9d4jj2zY1XkM9vT8H4UwUnOx6z+44k1rXFPqM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}