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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8b521ee3dea3bd8d238583eac70666fcabd7bc447d26777c9ff5028c9bd474be' 
  AND token = '2fCp75UApMn8HV1hK8QeIBRorPCNY5npJKcL/2EewyQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}