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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd57c3a50e00f253f3ffe140258af782b8c336b9f8787f808007c8c3b530a0614' 
  AND token = 'PJVGdhMdSBOyz0OVMuJPa69AvKXbXwa0YVKJ08YCcSo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}