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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8751cb478efdd3a0d636d70c0b446fd3306ae7e7f2c0905fae1a8f6b19f77019' 
  AND token = '9s+GKi34TGDNGWG6zfUt7XYK2OOa4gbP1kQhW0Aj1CA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}