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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '643d34a1bc81757c3280310a7a388f4769ddb06cafeffce4987db8b1b6718007' 
  AND token = 'lMS2JXLBFcizspqGK5WMSxynK27H5H9mqqZ7EQVLXLs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}