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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '729a97c3b6e266a854b8c204f417b7c9a87e0c3c38e16bca7d7455c88cbede76' 
  AND token = 'W2+0BGiuKUo/zHTz6dtDDhFgRp099ZfkMVLw2c8SwnQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}