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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22044ccd21d854040042d972bc6ea3cfa609af34c50fd0d2188eabf0f00ba2eb' 
  AND token = 'pwqY7j+S+IX5pLmO8LCp6SHupDGoDl7NtJJI4nSyIM0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}