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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c324b69009b1106e41faabfabe0f0f33a35ec5d7a65406f555e18b653302f40a' 
  AND token = 'e0OHoVLK6xH1/v5GMVcGcT7PwxbUprUKAb0jwhb9Wow=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}