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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9954e22c23386e2da5f0280f14923fe4de7d1004a97ead1df89d1e4e400a8675' 
  AND token = 'w1cxdJtcw1dG1rCMOyI8WeD3n5v1V4YTKcqHPhHFCjw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}