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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81281c9052362abc0ffe74f7fb92fe475d4d9b1ce24f192e940c257a12326051' 
  AND token = 'nMbU+4vtPOkgGaCE3rdx4sCCL4sHRbor6BLBO5/A9uk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}